Reward System and Addiction

REWARD SYSTEM AND ADDICTION

Addiction: A Disease of Learning and Memory http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16055762&query_hl=1

Addiction: making the connection between behavioral changes and neuronal plasticity in specific pathways. http://molinterv.aspetjournals.org/cgi/content/full/2/3/146

Addiction Pathways and Dendritic Changes http://web.sfn.org/content/Publications/BrainBriefings/addiction.html

ADDICTIVE DRUGS

Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: a horseradish peroxidase study in the rat. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=489776

Alcohol promotes dopamine release in the human nucleus accumbens. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12827641

Amygdalar control of the mesocorticolimbic dopamine system: parallel pathways to motivated behavior. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14599435

Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12872287
The Brain’s Drug Reward System http://www.nida.nih.gov/NIDA_Notes/NNVol11N4/Brain.html

The Brain on Drugs (Brain on Cocaine) http://www.drugabuse.gov/pubs/teaching/Teaching5/largegifs/slide07.gif

Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12151508

Cannabis and alcohol–a close friendship. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12823949BR
Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14623355

A common profile of prefrontal cortical activation following exposure to nicotine- or chocolate-associated contextual cues. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed

Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed

Conditioned release of corticosterone by contextual stimuli associated with cocaine is mediated by corticotropin-releasing factor. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?holding=npg&cmd=Retrieve&db=PubMed&list_uids=9554945&dopt=Abstract

Differential inhibition using contextual stimuli. http://www.nici.kun.nl/Publications/1996/6663.html

The dopamine-containing neuron: maestro or simple musician in the orchestra of addiction? http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12707003

Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12359667

DRUGS AND SPORTS

Effects of contextual priming on reactions to craving and withdrawal stimuli in alcohol-dependent participants. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11534545

Environmental stimuli promote the acquisition of nicotine self-administration in rats. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12202970

Functional imaging and neurochemical correlates of stimulant self-administration in primates. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12373436

GABAergic mechanisms of heroin-induced brain activation assessed with functional MRI. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12417998

How Drugs Influence Transmitters in the Brain http://www.macalester.edu/~psych/whathap/UBNRP/Dopamine/opioids.html

ILLUSTRATIONS

Ionic Mechanisms of Neurotransmitters, Drugs and Alcohol on Brain Neurons http://www.uic.edu/depts/mcpb/pages/appel/appel.htm

Long-Lasting Resistance to Extinction of Addictive Behavior Induced by Ethanol-Related Stimuli http://www.scripps.edu/research/sr2002/np18.html

The Memory of Drugs (Activation of Amygdala) http://www.drugabuse.gov/pubs/teaching/Teaching5/largegifs/slide10.gif

Memory processes in addiction http://homepage.mac.com/sanagnos/research.html

Neuroanatomy and Physiology of the “Brain Reward System” in Substance Abuse http://ibgwww.colorado.edu/cadd/a_drug/essays/essay4.htm

Neurochemical and behavioral studies on ethanol and nicotine interactions. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15019421

NEUROCIRCUITRY OF ADDICTION PAGE 1 PAGE 2

NIDA SITES

Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15009670

Passive exposure to a contextual discriminative stimulus reinstates cocaine-seeking behavior in rats. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed

The Pleasure Centres http://www.thebrain.mcgill.ca/flash/a/a_03/a_03_cr/a_03_cr_que/a_03_cr_que.html

The Pleasure Centres Affected by Drugs http://www.thebrain.mcgill.ca/flash/a/a_03/a_03_cr/a_03_cr_par/a_03_cr_par.html

The Reward Pathway http://www.drugabuse.gov/pubs/teaching/Teaching3/largegifs/slide-4.gif/P

Role of different nicotinic acetylcholine receptors in mediating behavioral and neurochemical effects of ethanol in mice.Alcohol. 2002 Nov;28(3):157-67. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12551757

Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12559839

[Sugar triggers our reward-system. Sweets release opiates which stimulates the appetite for sucrose–insulin can depress it] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15962882&query_hl=

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