Bidirectional astrocyte-neuron signaling occurs between specific neuron and astrocyte subpopulations

From MedicalXpress:

Astrocytes found to play a key role in regulating neural networks

August 14, 2015 by Bob Yirka


(Medical Xpress)—A small team of researchers with members from research centers in Spain and the U.S. has found that astrocyes appear to play a previously unknown key role in regulating neural networks in mouse brains. In their paper published in the journal Science, the team describes their study of a type of glial cell in a certain part of the mouse brain, and what they learned about neural networks in doing so. Aryn Gittis and Daniel Brasier with Carnegie Mellon University offer a Perspective piece on the work done by the team and describe possible implications of their findings.

Glial cells exist wherever there are —they surround neurons providing support for them and also serve as spacers, keeping the neurons apart. They are the most numerous cells in the nervous system. One type of glial cell, the star shaped astrocytes, are known to be active participants in neural communications via the transmission of gliotransmitters. In this new effort, the research team learned more about the role astrocytes play in neural communications and in so doing discovered that under certain circumstances when astrocytes activate one neuron, the responsiveness of another was enhanced. They also found that under other circumstances, the opposite could occur, when one neuron was caused to be excited, another nearby was simultaneously suppressed.

To learn more about the role astrocytes play in , the researchers used transgenic mouse lines fluorescently to identify communications between them and what are known as medium spiny neurons, located in the striatum—what they really wanted to know though, was whether certain astrocytes couple with certain neurons, or whether there are less specific couplings that occur. A closer look using triple whole-cell electrical recordings from two of the heterotypic neurons and a single astrocyte suggested the former—they apparently only communicate with specific subtypes of adjacent neurons.

Read more.


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