Inhibitory basket cells play important role in synchronization of brain networks

From MedicalXpress:

Neuroscientists investigate how 100 billion nerve cells produce a clear thought or an action

Neuroscientists investigate how 100 billion nerve cells produce a clear thought or an action

Intracellular filled hippocampal basket cells (magenta) and granule cells (green) with a schematic illustration of the distance-dependent inhibition. Credit: Michael Strüber

We have approximately 100 billion nerve cells in our brains, all of which communicate with one another. Why do they lead to clear thoughts or purposeful actions instead of mere gibberish? The reason lies, among other things, in a small group of inhibitory nerve cells that can use the messenger GABA to curb the activity of other nerve cells. The neuroscientists Dr. Michael Strüber and Prof. Dr. Marlene Bartos from the University of Freiburg and their colleague from Vienna Prof. Dr. Peter Jonas have discovered that the distances between communicating cells play a part in the regulation of brain networks. The team presents this approach in the current issue of the journal Proceedings of the National Academy of Sciences (PNAS).

GABA is released at special contact points, synapses, from a projection of the that serves precisely this purpose, the axon. The messenger causes an electrical inhibitory current in the target cells. A special subtype of the GABA-releasing cells is the so-called basket cell. It is known to have a strongly inhibitory effect on brain circuits. A reason for this is the fact that basket cells have a long and widely branching axon, with which they can control hundreds to thousands of target cells scattered over a broad area. Up to now it was not clear whether all of these target cells are subject to the same inhibitory current or whether target cells that are more distant from the GABA-releasing basket cell are more difficult to keep under precise control.

With the help of the patch-clamp technique for measuring the inhibitory currents of , the team discovered that the farther away a is, the smaller and longer are their inhibitory currents. In pharmacological and electrophysiological experiments and by means of detailed microscopic studies, the neuroscientists demonstrated that the basket cell axon with more distant target cells forms less synapses and that other proteins capable of sensing GABA are found in these synapses.

What could be the reason for such a complex structure? While this question cannot be answered in its entirety, the scientists investigated the consequences of a distance-dependent inhibition in computer simulations of neuronal networks. Contrary to expectations, the weakening inhibition enables the to precisely control the activity of a large number of nerve and thus to synchronize them.

Read more.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s