Malfunction of cellular protein transport hub may play a role in neurodegenerative diseases

From UQ News:

Molecular 'transport hub' protein structure
Molecular ‘transport hub’ protein structure

9 October 2014

University of Queensland researchers have gained new insights into how the body sorts and transports protein ‘cargo’ within our cells, in a finding that could eventually lead to treatments for neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

An international research team co-led by Dr Brett Collins from UQ’s Institute for Molecular Bioscience has revealed the structure of a molecular transport hub that sorts, directs and transports protein to correct destinations in the cell.

Dr Collins said protein cargoes that failed to reach the correct destinations in cells created ‘traffic jams’ that could affect neuronal activity and brain function.

“Having an understanding of how these proteins work together to sort and transport cargo could be the first step in developing drugs that reverse the effects of toxic protein accumulation in neurodegenerative disease,” he said.

Dr Collins has been studying how cargo is sorted, packaged, and trafficked within human cells for more than a decade.


“If we can enhance or improve the function of this protein we could potentially slow down the brain degeneration that occurs in diseases such as Alzheimer’s and Parkinson’s,” he said.

The study, published in leading scientific journal Proceedings of the National Academy of Science, involved scientists from IMB, the University of Bristol’s School of Biochemistry, and The Henry Wellcome Integrated Signalling Laboratories.

Read more.


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